Brand UPO, Università del Piemonte Orientale
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Pharma Analytics

Team Leader
Grosa Giorgio

Activity and fields of competence

Analysis of drugs and bioactive compounds in complex matrices.

  1. Chemical and metabolic stability studies of drugs using LC-DAD-UV and LC-MS / MS techniques
  2. Characterization of bioactive substances in complex matrices by LC-MS / MS and GC-MS analysis

Studies of chemical (A) and metabolic stability of drugs (B).

  • A1) Forced degradation studies of drugs with identification and synthesis of degradation products. Characterization of drug impurities.
  • A2) Development and validation of LC-DAD-UV, Uv-Vis and LC-MS / MS methods for the determination of active ingredients and degradation products in pharmaceutical formulations
  • B1) In vitro / in vivo metabolic stability studies (animal / human model): identification and synthesis of metabolites
  • B2) Identification studies of the isoforms involved in drug metabolism
  • C) Qualitative and quantitative determination of pollutants and contaminants (eg pesticides) by LC-MS / MS and GC-MS / MS analysis.

Characterization and quantitative determination of active ingredients (bioactive substances) in complex natural matrices (e.g., plant extracts) by LC-MS and GC-MS analysis

Technological Resources

  • N ° 2 Shimadzu HPLC systems equipped with: two LC-10 AD Vp pumps; an SLC-10 A Vp control module; SPD detector M10A Vp; SIL-10DAVp auto sampler; DGU 14A degasser system; LCsolution software 1.24
  • N ° 1 Waters DELTA 600 preparative HPLC system equipped with: quaternary pump; Water 600 control module; Waters 2487 UV detector; Empower software
  • N ° 1 UV-Vis Lambda 35 spectrophotometer (Perkin-Elmer) equipped with Winlab software.
  • N ° 1 Thermo Finningan LCQ Deca XP plus HPLC-UV-MS / MS system equipped with: quaternary pump, Surveyor AS autosampler, DAD Surveyor detector, electrospray ion source (ESI) and athmospheric pressure chemical ionization (APCI) source; Xcalibur® software
  • N ° 1 Thermo Finningan Polaris Q GC-MS / MS system equipped with gas chromatograph and ion trap mass spectrometer with EI and CI ionization; Xcalibur® software

ERC Sector

PE4, PE5, PE5_16

Team members

Last modified 18 July 2022